Based on data for European women, there was evidence of association for both ER-positive (OR = 1.06, 95% CI = 1.04–1.08, P = 3.2 × 10−8) and ER-negative breast cancer (OR = 1.04, 95% CI = 1.01–1.07, P = 0.019; P = 0.47 for difference in OR by ER disease).There was no evidence of differences in the OR by age (P = 0.58), family history (P = 0.74) or any of the other tumor characteristics considered (PR status, HER2 status, axillary node status, grade, size or morphology; P ≥ 0.084). The gene discussed is ERBB2; the disease is neoplasm.