Among the cancer genes mutated in patient CLN2 were APC, KRAS, PIK3CA, SMAD4, MYST4, HUNK, INPPL1, TGFβ3, and TCF7L2. Cancer genes mutated in CLN3 included KRAS, INPP4B, PTPRE, CARD16 and LRP2. Cancer gene mutations in CLN4 were detected in APC, KRAS, PIK3CA, KDR and AURKC (Table 3). The gene discussed is SMAD4; the disease is cancer.