IL10RA and infection: Treatment of high-dose infection in AKR mice (which will naturally progress to chronic infection) with anti-IL-10R monoclonal antibody only during the chronic phases of infection interfered with control of gross pathology (Fig. 3C), crypt hyperplasia, and intestinal epithelial cell turnover (Fig. 3D), a situation more reminiscent of the infected C57BL/6 strains.