Overall, the apparent skewing in cytokine production could be observed as a differential response to LPS stimulation in the presence of DHPG compared with LPS alone (Figure 1A-D); such that TD controls displayed a significantly lower production of IL-6 (median −17.3% (interquartile range −33.0 to −0.4%) versus 11.4% (−11.7 to 43.6%); P = 0.02) and IL-12(p40) (median −48.7% (interquartile range −69.7 to −19.8%) versus 0% (−21.1 to 43.4%); P < 0.01) in the presence of DHPG compared with children with FXS. Here, IL6 is linked to fragile X syndrome.