The average CLDQ score of the 108 antiviral-treated patients was 5.23 in this study, indicating a moderate reduction in quality of life among antiviral-treated CHC patients and it is a lower score than that of chronic hepatitis patients treated with IFN-α in Tehran, Iran (5.40)[37], and much lower than norms in the USA (5.9)[38]. Here, IFNA1 is linked to cryohydrocytosis.