As summarized in Table 2, there was a statistically significant difference between the high-proliferation group (Ki-67 labeling index >10%) and the low-proliferation group (Ki-67 labeling index ≤10%) in both the lung squamous cell carcinoma and adenocarcinoma samples (P<0.05), suggesting that TC-1 expression is strongly correlated with the cell proliferation of NSCLC. This evidence concerns the gene MKI67 and squamous cell lung carcinoma.