As shown in Figs. 7A and 7B, compared with the MOCK group, the PD(+), CIS(+), and PD+CIS(+) groups exhibited significant inhibition of A549 cell proliferation and prolonged survival of the tumor-bearing animals, particularly the PD+CIS(+) group, which presented an additional inhibitory effect and survival benefit compared with the other groups. Here, CISH is linked to neoplasm.