FGFR3 and urinary bladder cancer: In bladder cancer, PD173074 markedly suppresses cell proliferation in two cell lines (UM-UC-14 and MGHU3) that express the mutated FGFR3 protein in vitro and in vivo, and further analysis revealed that the growth inhibitory effect of PD173074 is associated with arrest at G1-S transition and induction apoptosis in a dose-dependent manner [19].