Another study indentified rs10318 (GREM1), rs6983267 (POU5F1P1, DQ515897, MYC) and rs4464148 (SMAD7) associated with clinic outcome in patients with stage II and stage III CRC treated with 5-FU-based adjuvant chemotherapy [62]. This evidence concerns the gene GREM1 and colorectal carcinoma.