APC and colorectal carcinoma: In fact, most of sporadic CRC are strongly linked to environmental factors, by which the most often mutations in adenomatous polyposis coli (APC) tumor suppressor gene lead to destruction of Apc/GSK3β/Axin complex and activation of Wnt/β-catenin pathway [2], [5], [6] Aberrant activation of Wnt/β-catenin pathway not only promotes proliferation of intestinal epithelial cells but also induces their arrest as they move towards the end of the crypt and prevent shedding or apoptosis of transformed cells.