Recent studies have reported that TRAIL suppresses chemokine (C-X-C motif) receptor 4 (CXCR4) -mediated human breast cancer cell migration by up-regulating miR-146a expression through NF-κB signaling [46], and that miR-146 regulates epigenetic regulator UHRF1 and modulates gastric cancer invasion and metastasis [47], showing the important roles of miR-146 in inhibiting cancer metastasis by interfering chemokine and epigenetic regulator. This evidence concerns the gene CXCR4 and cancer.