Of the 186 patients who underwent liver biopsy (171 in the abnormal ALT group and 15 in the PNALT group), the 21 with CB2-63 QQ showed a higher (mean±SD: 7.81±4.1) HAI than the 107 with CB2-63 QR (5.6±3.3, p = 0.008) and the 58 with CB2-63 RR (5.5±3.5, p = 0.017), whereas no statistically significant differences were observed in the degree of liver fibrosis and steatosis. The gene discussed is GPT; the disease is Hepatic fibrosis.