Similar prevalences of CB2-63 QQ variant were observed in these two cohorts, both in PNALT subjects (1st cohort 31% of 35 subjects; 2nd cohort 38% of 18 subjects) and chronic hepatitis patients (1stcohort 10.7% of 130 patients; 2nd cohort 11.4% of 70 patients). The gene discussed is CNR2; the disease is chronic hepatitis.