In a study evaluating IL-10 administration in 30 patients with HCV-related liver disease, Nelson et al showed that IL-10 caused a decrease in the number of HCV-specific CD4+ and CD8+ IFN-gamma secreting T cells and alterations in PBMC cytokine production towards a Th2 dominant profile, as well as an improvement in the ALT serum levels [53]. The gene discussed is CD8A; the disease is liver disorder.