Considering that the above-mentioned CB2-mediated inhibition of T-cell proliferation was normal in CB2-63 QQ subjects and reduced in RR subjects [6], [7], it has been hypothesized that the hepatic inflammation associated with liver steatosis is inhibited in CB2-63 QQ subjects [48], a hypothesis in good agreement with experimental observations showing the hepatoprotective properties of CB2 agonists in the mouse model of carbontetrachloride (CCl4)-induced liver injury. The gene discussed is CNR2; the disease is injury.