GADD45A and acute respiratory distress syndrome: These studies identified a significant association of the GADD45a promoter SNP rs581000 with allele C reducing the risk of both sepsis and ALI in AAs from Chicago (p = 0.009, adjusted p = 0.05 under a dominant model) and in Spanish subjects (p = 4.20E-06, adjusted p value = 0.00003 under a dominant model, FDR <1%) (Figure 3A and Table 3).