With respect to clinicopathological features, CD133 level was positively correlated with lymph node metastasis (OR = 1.99, 95%CI = 1.06–3.74, P = 0.03), but not correlated with the histological classification (OR = 1.00, 95%CI = 0.81–1.23, P = 0.99(ac), OR = 0.87, 95%CI = 0.61–1.24, P = 0.45(sc)), or differentiation (OR = 0.94, 95%CI 0.53–1.68, Z = 0.20, P = 0.84 random-effect) of NSCLC patients. Here, PROM1 is linked to non-small cell lung carcinoma.