Concordance, Univariable and Multivariable Cox analyses of overall survival and progression-free survival in 138 patients, with metastatic colorectal cancer treated with 3rd line cetuximab and irinotecan according to a miRNAs, gender, age, performance status and KRAS and, PI3KCA mutation status. miRNAs are tested as continuous variables in interquartile ranges units. This evidence concerns the gene KRAS and metastatic colorectal cancer.