The results of the western blot analysis conducted in the present study showed that glycyrrhizin significantly suppressed the phosphorylated-p38 protein level, demonstrating that glycyrrhizin attenuated the I/R-induced activation of p38 MAPK signaling, which resulted in a protective effect against renal cell apoptosis and inflammatory responses in I/R-induced kidney injury in mice. The gene discussed is MAPK14; the disease is kidney injury.