Because VEGFA is a key stimulator of vasculogenesis and angiogenesis for all vertebrates, and over-expression of VEGFA is not only associated with developmental vascular abnormalities, but also contributes to various diseases including cancer (Drake and Little, 1995), we were motivated to determine whether the VEGFA-regulating function of SerRS is conserved in higher vertebrates such as humans, and what is the mechanism by which nuclear SerRS controls VEGFA expression. Here, VEGFA is linked to cancer.