In addition, as application of 1α,25(OH)2D3 to treat human ICC SNU1079 cells, which express VDR (Fig. 4a), a dose dependent antiproliferation and downregulation of LCN2 mRNA and protein expressions was observed (Fig.4b,c,&d). The gene discussed is LCN2; the disease is intrahepatic cholangiocarcinoma.