To further determine LCN2 effect on human CCA cells, we knockdowned LCN2 in another CCA cell line, SNU308, and obtained SNU-COLsi cells (mock knockdown SNU308 cells) and SNU-NGALsi cells (LCN2 knockdwon SNU308 cells)(Figure S-3). Here, LCN2 is linked to cholangiocarcinoma.