TLR4 and coronary artery disorder: Saturated fats interact with another bacterial receptor, TLR2 and its co-receptor CD14 (which is shared with TLR4), and thus may impact infectious outcomes for both Gram-negative infections such as E. coli as well as Gram-positive infections like Staph. aureus and have even be implicated in coronary artery disease pathogenesis [49,52,59,60].