CD4 and hand, foot and mouth disease: The numbers of peripheral CD3+ (p = 0.023) and CD3+CD4+ (p = 0.039) cells in the uncomplicated HFMD group were substantially higher than those in the HFMD with encephalitis group, whereas the number of peripheral CD3−CD19+ cells (p = 0.001) was significantly lower in the uncomplicated HFMD group compared to the HFMD with encephalitis group (Table 2).