We also found the similar results in NCI-H1975 and NCI-H460 tumor models (Figure 6A).To evaluate the potential antiangiogenic mechanism of AZD6244 and BEZ235, gefitinib-resistant NSCLC tumor tissues were analyzed by immunostaining for CD31 (platelet endothelial cell adhesion molecule 1). This evidence concerns the gene PECAM1 and neoplasm.