However, ESR2 gene expression is characteristic feature of a normal colon epithelium, and it is downregulated in CRC; in addition, its decreased expression has been associated with Duke’s stage [45], and, according to Konstantinopoulos et al., the loss of ESR2 expression is associated with the disability of cancer cells to differentiate [46]. The gene discussed is ESR2; the disease is colorectal carcinoma.