In the SW480/WWOX colon cancer cell line, the expression of genes regulating the cell cycle (CCNE1, KI67) and signal transduction (EGFR) were found to be significantly downregulated, in contrast to the expression of ERBB4 JMa-1 and the suppressor gene PTEN. More detailed information, i.e. mean gene mRNA expression and calculated fold change for each gene between cell line variants, is presented in Table 1. The gene discussed is ERBB4; the disease is colonic neoplasm.