On the other hand, Tanimoto et al. reported that serum VEGF levels measured using the same methodology as in the Jacobsen et al. study and assessed using a cut-off value (400 pg/mL), as determined using ROC analysis in 45 patients with CCRCC, were not significantly correlated with tumor stage, pathological grade, tumor size or prognosis [25]. The gene discussed is VEGFA; the disease is neoplasm.