NPPA and hydrops fetalis: The increased heart weight in the HF + Rosi group was accompanied by an upregulation of the fetal/stress genes B-type natriuretic peptide (Bnp) (2.43 ± 0.33; P < 0.001; Figure 2B) and atrial natriuretic peptide (Anp) (1.62 ± 0.44; P < 0.01; Figure 2C), relative to the HF group (Bnp, 1.0 ± 0.14; Anp, 1.0 ± 0.14).