To further define the potential roles of the ERBB2/RAS pathway in promoting prostate cancer metastasis, we have examined the effects of overexpression of ERBB2 or RAS on the metastatic properties of three human prostate cancer cell lines and one murine prostate cancer cell line with various levels of androgen sensitivities and different metastatic potentials. Here, ERBB2 is linked to Familial prostate cancer.