Our results show that nuclear p53 expression was significantly greater in the P-AD and N groups than in the CP-AD group (Figure 2A; Table 4; Figure S5A, S5B, and S5C); however, for cytoplasmic expression, there were no significant differences among the groups (Figure 2B; Table 5; Figure S5D, S5E, and S5F). The gene discussed is TP53; the disease is Alzheimer disease.