NR0B1 and chronic primary adrenal insufficiency: Similar to DAX1 (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1; NR0B1) [38], SHP (Small Heterodimer partner, NR0B2) [39] and PNR [37], the structural alignment used for designing the TLX LBD model (Fig. 1) revealed that it is shorter than other NR LBDs and lacks the first helices α1 and α2.