IRF6 and van der Woude syndrome: Mutations in the IRF6 gene (OMIM:607199) have been reported worldwide to cause VWS and PPS (Kondo et al. 2002; De Lima et al. 2009; Birkeland et al. 2011; Miñones-Suárez et al. 2012; Salahshourifar et al. 2012; Leslie et al. 2013; Malik et al. 2013; Tan et al. 2013).To date, about 300 mutations causing VWS and PPS have been reported in different populations across the world (Leslie et al. 2013) and these include missense, nonsense, and frameshift, microdeletions and splice-site mutations.