SATB2 and Down syndrome: Oral clefts are common in Thailand and genetic studies have demonstrated many genetic susceptibility loci and new mutations (Shotelersuk et al. 2003; Srichomthong et al. 2005, 2013; Tongkobpetch et al. 2006, 2008; Suphapeetiporn et al. 2007; Rattanasopha et al. 2012), including p63 which causes an isolated cleft lip (Leoyklang et al. 2006), and SATB2 which causes a unique dysmorphic syndrome with intellectual deficit, SATB2-associated syndrome (SAS) (Leoyklang et al. 2007, 2013).