Recently, it has been demonstrated in a Brca, Tp53, Pten genetic mouse model that de novo high grade serous ovarian carcinoma are originated from the fallopian tube secretory epithelium and that these tumours are correlated with high grade serous carcinoma tumour markers and genomic alterations of the human TCGA data set[29]. This evidence concerns the gene TP53 and ovarian serous carcinoma.