BACE1 and Alzheimer disease: Further characterization of BACE1-AS in a transgenic mouse model of AD indicated that BACE1-AS inhibition reduces the insoluble fraction of Aβ 1–40 and Aβ 1–42 precursor proteins (Modarresi et al., 2011), suggesting that increased BACE1-AS expression does directly contribute to AD pathology.