CD8A and malaria: The critical role of CD8 T cells in protection against liver-stage malaria has been confirmed upon immunization with different formulations, such as recombinant vaccines [e.g., Salmonella typhimurium, vaccinia virus or adeno virus expressing P. berghei circumsporozoite (CS) protein] and genetically attenuated parasite (GAP; Sadoff et al., 1988; Lanar et al., 1996; Rodrigues et al., 1997; Jobe et al., 2007).