In a separate study, we showed that exposure of mice to infections with unrelated pathogens (e.g., LCMV, LM, VacV, MHV-1) following DC-LM CS prime/boost vaccination induces dramatic decreases in frequency, but also in total numbers of antigen-specific memory CD8 T cells (Schmidt and Harty, 2011). The gene discussed is CD8A; the disease is infection.