HTR1A and major depressive disorder: In particular, this polymorphism has been associated with major depression (Lemonde et al., 2003; Kishi et al., 2013), bipolar depression (Kishi et al., 2013), completed suicide (Wasserman et al., 2006) (although not suicidal ideation or attempt) and anxiety disorders as well as reduced response to SSRI and antipsychotics that target 5-HT1A receptors (Le François et al., 2008; Newman-Tancredi and Albert, 2012).