The pH-responsive PDEA layer is hydrophobic and collapses on the core at the physiological pH (7.4) which can prevent the premature burst drug release, but it becomes highly positively charged by protonation of the pendant tertiary amine groups and could lead the micelles to be adsorbed onto negatively charged cell membranes and subsequently endocytosed by tumor cells at tumor extracellular pH. Here, PDE6A is linked to neoplasm.