PDHX and colonic neoplasm: It indicated that the inhibition of miR-26a in SW620 cells could cause similar glucose metabolic effects that were obtained in HCT116 cells.All these results have demonstrated that miR-26a inhibits the conversion of pyruvate to acetyl-CoA though directly targeting the PDHX (Figure 8), which accelerates the glucose consumption to undergo aerobic glycolysis for meeting their increased energy and biosynthesis in colon cancer cells.