Similarly, pain sensitivity was linked to P2RX7 gene polymorphisms in women with post-mastectomy pain (PMP) and osteoarthritis (OA), with those carrying the gain-of-function (GOF) Tyr155 allele at rs208294 (H155Y)[22] reporting more pain than carriers of the His155 allele. Here, P2RX7 is linked to osteoarthritis.