It is, however, important to note that despite the small number of cases analyzed, we recorded significant associations between DVL3 expression levels between the metastases originating from various primary tumors, upregulation of DVL1 and DVL3 and nuclear beta-catenin staining and also association of CDH1 genetic changes and diagnoses adenocarcinoma and SCLC. Here, CTNNB1 is linked to adenocarcinoma.