APOE and atherosclerosis: Among all the miRNAs examined, significantly upregulated expression of miR-21, miR-26a, and downregulated expression of miR-20 was observed in aortas in NR1-treated ApoE−/− mice compared to that from the vehicle-treated ApoE−/− mice (Table 3), suggesting that NR1 may exert the anti-atherosclerotic effects in part through modulating the expression of regulatory miRNAs in atherosclerosis.