APOE and atherosclerosis: In distinct contrast to that from the vehicle-treated ApoE−/− mice, atherosclerotic lesion was noted to be alleviated in NR1-treated ApoE−/− mice (Figure 1c), Further quantification of the atherosclerotic lesion in the aortic root showed that the extent of atherosclerosis lesion was significantly reduced in NR1-treated ApoE−/− mice compared to that from the vehicle-treated ApoE−/− mice (12.09±4.10% in NR1-treated mice vs. 36.30±5.47% in vehicle-treated mice, p = 0.018) (Figure1d).