After adjusting for age, sex, histology, stage, ECOG performance status, smoking status, radiation therapy, and adjuvant chemotherapy in the Cox model, ERCC1 rs11615 AA genotype predicted a higher risk of death in early stage patients with squamous cell carcinoma (HR = 6.633, 95% CI = 1.184−37.164, p = 0.031), those ever smoked (HR = 3.324, 95% CI = 1.040−10.627, p = 0.043), those with ECOG performance status of 1 (HR = 2.835, 95% CI = 1.063−7.560, p = 0.037), or those never receiving radiation therapy (HR = 5.381, 95% CI = 1.857−15.593, p = 0.002). This evidence concerns the gene ERCC1 and squamous cell carcinoma.