Our initial attempts to recapitulate MIF/D-DT-deficiency using small molecule MIF antagonists indicate that the irreversible MIF inhibitor, 4-iodo-6-phenylpyrimidine (4-IPP) [33], strongly inhibits NSCLC clonal proliferation in a manner similar to that observed in MIF/D-DT-deficient cells. This evidence concerns the gene MIF and non-small cell lung carcinoma.