In conclusion, with this case report, we would like to emphasize that (i) patients diagnosed with bilateral optic nerve hypoplasia should be investigated for anterior pituitary hormone deficiencies, (ii) inappropriate acceleration of growth velocity and rapid improvement in bone age may be predictive for CPP development during the follow-up of SOD patients receiving GH therapy. This evidence concerns the gene SOD1 and Autosomal dominant optic atrophy, classic type.