INS and type 1 diabetes mellitus: While ecto-pancreatic transplantation of donor pancreas has proven efficient in normalizing blood glucose levels, hemoglobin A1c , secretion of insulin and C-peptide, recent studies by Shapiro et al (7,8,9,10,11), showing impressive results in reversing T1DM following islet implantations in patients with severe metabolic instability, have focused attention on this intervention strategy.