The SNP rs4444235 at chromosome 14q22.2, mapping 9.4 kb upstream region of the gene encoding bone morphogenetic protein 4 (BMP4), was firstly reported by a meta-analysis of GWAS data to be associated with CRC risk, with a combined OR of 1.11 (95% CI = 1.08–1.15, P = 8.1×10−10) [6]. Here, BMP4 is linked to colorectal carcinoma.