SAMHD1 and HIV-1 infection: It has been reported that DCAF1/VprBP is recruited by HIV-2/SIVsmm/mac Vpx to hijack the CUL4–DDB1 E3 ubiquitin ligase complex for degradation of host-restrictive factor SAMHD1 [34], [35], [53], facilitating HIV-1 infection in myeloid cells.