AHR and cancer: AhR knockdown resulted in down-regulation of the expression of two anti-apoptotic genes, Baculoviral IAP repeat containing 3 (BIRC3) and B-cell CLL/lymphoma 3 (BCL3). Both BIRC3 and BCL3 function to inhibit apoptosis and their elevated expression has been observed in a number of cancers [24]–[26].