PAH-induced AhR activation increases the transcription of a variety of genes encoding phase I drug metabolizing enzymes, such as CYP1A1 and CYP1B1, and phase II drug metabolizing enzymes, such as glutathione-S-transferase A1 (GSTA1) and UDP glucuronosyl transferase 1A2 (UGT1A2). Here, AHR is linked to pulmonary arterial hypertension.