To further explore the molecular mechanism of the inhibition of DAPT on EMT in human GC cell lines, the expression of the epithelial marker, E-cadherin and mesenchymal markers, such as vimentin, N-cadherin and Snail, were examined in AGS and MKN45 cells in the presence of DAPT or DMSO. This evidence concerns the gene CDH2 and gastric cancer.