AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: The aim of the present study was to investigate whether resveratrol has potential antitumor effects in human CML and to determine whether the modulation of the PI3K/Akt/mammalian target of rapamycin (mTOR) signaling pathway by resveratrol is crucial for its anticancer effects in the human CML K562 cell line.