In conclusion, the present study demonstrated that resveratrol downregulates and inactivates the PI3K/Akt/mTOR signaling pathway, which may exhibit a critical function in resveratrol-induced apoptosis in K562 cells and, therefore, the PI3K/Akt/mTOR signaling pathway may present a potential therapeutic target for the treatment of human CML. The gene discussed is AKT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.