Other studies have also shown the prognostic value of squamous cell carcinoma (SCC) antigen (9–11), carcinoembryonic antigen (CEA) (11–13), carbohydrate antigen 125 (CA125) (11,14) and even neuron-specific enolase (NSE) (15) in non-small cell lung cancer. The gene discussed is ENO2; the disease is squamous cell carcinoma.