Fascin has emerged as an interesting potential biomarker due to its low or absent expression in the majority of normal adult epithelia; colonic (9), breast (10), ovarian (11), stomach (12), pancreas (13), oral cavity (14,15), oropharynx (15), nasopharynx (16) and larynx (17), yet fascin upregulation has been reported in all types of human carcinoma that has been studied to date (17,18). This evidence concerns the gene FSCN1 and carcinoma.