IDH2 and neoplasm: In addition, the lobar distribution of the neoplasms was analyzed in all patients and the IDH-mutated tumors were more frequently located in a single lobe, such as the frontal lobe, temporal lobe or cerebellum, whereas the IDH wild-type tumors were predominantly located in combined lobes, such as the diencephalon or brain stem (P<0.001; χ2 test; Table II).