Significant associations have also been reported between MRI characteristics and genotype in oligodendrogliomas, oligoastrocytomas or glioblastomas (20,29,31–37), however, IDH mutation status was not addressed in these studies, with the exception of that by Metellus et al. Consistent with the results reported by Metellus et al (20), the present study also revealed that IDH-mutated gliomas are significantly more likely to exhibit sharp tumor margins. The gene discussed is IDH2; the disease is central nervous system cancer.