Polytarchou et al.[28] provided evidence that a hypoxia-activated, Akt-dependent pathway is present in ovarian cancer where the microRNA miR-21 is induced by Akt and subsequently targets and downregulates Spry1, PTEN and programmed cell death 4 (PDCD4), resulting in enhanced cell survival. The gene discussed is PDCD4; the disease is ovarian carcinoma.