Current study found that, in human prostate carcinoma cell line DU145, glucosamine reduced N-glycosylation of IL-6 receptor subunit gp130 by inhibiting co-translational N-glycosylation, resulting in less IL-6 binding to cells and less phosphorylation (activation) of down-stream JAK2 and STAT3 proteins. Here, IL6 is linked to prostate carcinoma.