Our results indicated that the levels of SHP2 transcript (Figure 1A) and SHP2 protein (Figure 1B) were significantly upregulated in tissue samples obtained from patients with oral cancer, and that SHP2 is required for the in vitro invasion of oral cancer cells to Matrigel (Figure 2A and B) and in vivo metastasis of oral cancer cells toward the lung in mice (Figure 5). The gene discussed is PTPN11; the disease is lip and oral cavity carcinoma.